Universal Chrome Bullet Motorcycle Turn Signal Light for Harley Bobber Softail Other Motorcycle Lighting & Indicators


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Universal Chrome Bullet Motorcycle Turn Signal Light for Harley Bobber Softail
Condition: New Brand:

POSSBAY

Power: 10W Manufacturer Part Number:

Does not apply

Thread Length: 2 cm Material: Aluminum shell
Cable length: 30 cm Thread diameter: 10mm
Fitment: Universal fit for Harley Motorcycle Light Color: Amber
Package include: 2pcs turn signal light Voltage: 12V
UPC:

Does not apply











published on tue nov 09 2021

Universal Chrome Bullet Motorcycle Turn Signal Light for Harley Bobber Softail Other Motorcycle Lighting & Indicators

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Universal Chrome Bullet Motorcycle Turn Signal Light for Harley Bobber Softail Other Motorcycle Lighting & Indicators

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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