Bus 6-LED 2X Van 12V Yellow/Amber Lamp Light Tail Marker Side Trailer Truck Boat Car & Truck LED Light Bulbs


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2X 6-LED Bus Van Boat Truck Trailer Side Marker Tail Light Lamp Yellow/Amber 12V
Condition: New other (see details) Country/Region of Manufacture: China
Manufacturer Part Number:

Does Not Apply

Brand:

Unbranded

UPC:

664132567468







published on tue nov 09 2021

Bus 6-LED 2X Van 12V Yellow/Amber Lamp Light Tail Marker Side Trailer Truck Boat Car & Truck LED Light Bulbs

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Bus 6-LED 2X Van 12V Yellow/Amber Lamp Light Tail Marker Side Trailer Truck Boat Car & Truck LED Light Bulbs

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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