2002 - 1994 Firebird Pontiac 16" 6516 C RIM WHEEL OEM FACTORY SPOKE 5 Other Car & Truck Wheels, Tires & Parts


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Pontiac Firebird  1994 - 2002 16" 5 SPOKE FACTORY OEM WHEEL RIM C 6516
Condition: Remanufactured Brand:

Alloy Wheel Repair Specialists

Quantity: 1 Rim Material: Alloy
Manufacturer Part Number:

9592444

Offset: 55 MM
Other Part Number: 12365442 Rim Diameter: 16 IN
Surface Finish: SPARKLE SILVER Rim Width: 8 IN
Interchange Part Number: 06516
published on tue nov 09 2021

2002 - 1994 Firebird Pontiac 16" 6516 C RIM WHEEL OEM FACTORY SPOKE 5 Other Car & Truck Wheels, Tires & Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

2002 - 1994 Firebird Pontiac 16" 6516 C RIM WHEEL OEM FACTORY SPOKE 5 Other Car & Truck Wheels, Tires & Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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