sign tin metal decor country cottage Tractor Ford equipment farm house art wall Novelty Home Décor Plaques & Signs


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farm equipment Ford Tractor cottage country decor metal tin sign house wall art
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Type: Wall Plaques
Shape: Rectangle Brand:

Unbranded

Item Length: 12 inches (30cm) Country/Region of Manufacture: China
Item Width: 8 inches (20cm) Material: Metal
UPC:

Does Not Apply





published on tue nov 09 2021

sign tin metal decor country cottage Tractor Ford equipment farm house art wall Novelty Home Décor Plaques & Signs

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

sign tin metal decor country cottage Tractor Ford equipment farm house art wall Novelty Home Décor Plaques & Signs

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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