Dress Pcs/lot 3 Apron JBCA Dolls s for Doll Clothes Chef Hat Custom, Handmade


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3 Pcs/lot Dress Apron Hat Chef Clothes Doll for s Dolls JBCA
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Original/Reproduction: Reproduction
UPC:

Does not apply

Doll Size: for 11in. Doll
EAN:

Does not apply

Features: Gift Set
ISBN:

Does not apply

Recommended Age Range: Above 3 Year old
Brand:

Unbranded

Country/Region of Manufacture: Hong Kong
MPN:

Does not apply

Era/Year: Unknown










published on tue nov 09 2021

Dress Pcs/lot 3 Apron JBCA Dolls s for Doll Clothes Chef Hat Custom, Handmade

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Dress Pcs/lot 3 Apron JBCA Dolls s for Doll Clothes Chef Hat Custom, Handmade

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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