Elephant the  Cage about Details Albums Y522 05 Cues Social 24x36s 14x21 Poster Cover Art Posters


  1. Home
  2. Elephant the  Cage about Details Albums Y522 05 Cues Social 24x36s 14x21 Poster Cover
  1. facebook
  2. twitter
  3. linkedin
  4. pinterest
Details about   Cage the Elephant Albums Cover Poster 14x21 24x36s Social Cues 05 Y522
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Originality: Reproduction
Style: Art Deco Listed By: Dealer or Reseller
Features: Unframed Color: White
Subject: Poster Date of Creation: 2000-Now
Quantity Type: Single-Piece Work





published on tue nov 09 2021

Elephant the  Cage about Details Albums Y522 05 Cues Social 24x36s 14x21 Poster Cover Art Posters

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Elephant the  Cage about Details Albums Y522 05 Cues Social 24x36s 14x21 Poster Cover Art Posters

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

509
1.2k
EVGENIA.RU RSS