For Vent Air AC Dash Grill Console Front BMW 535 530 528 525 523 520 Series 5 Car & Truck Interior Consoles & Parts


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Front Console Grill Dash AC Air Vent For BMW 5 Series 520 523 525 528 530 535
Condition: New Brand:

Unbranded

Color:

Black

Manufacturer Part Number:

BFCR01277

UPC:

631145172705

Other Part Number: 64229166885
EAN:

0631145172705









published on tue nov 09 2021

For Vent Air AC Dash Grill Console Front BMW 535 530 528 525 523 520 Series 5 Car & Truck Interior Consoles & Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

For Vent Air AC Dash Grill Console Front BMW 535 530 528 525 523 520 Series 5 Car & Truck Interior Consoles & Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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