Editions Atlas 2690-037 Sd.Kfz.223 Army German Model 1/43 Panzerspahwagen Tanks & Military Vehicles


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2690-037 Atlas Editions Sd.Kfz.223 Panzerspahwagen 1/43 Model German Army
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Brand:

Atlas Editions 1:43 Military Vehicles

Year of Manufacture: 2020 Scale: 1:43
Model:

Sd.Kfz.223 Panzerspahwagen

Vehicle Make: Auto Union
MPN:

2690-037_Diecast_Metal_Model_Auto_Union_Truck

Vehicle Type: Truck
Recommended Age Range: 14+ Material: Diecast Metal and Plastic
Country/Region of Manufacture: China Theme: 1:43 Military Vehicles
UPC:

Does Not Apply



published on tue nov 09 2021

Editions Atlas 2690-037 Sd.Kfz.223 Army German Model 1/43 Panzerspahwagen Tanks & Military Vehicles

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Editions Atlas 2690-037 Sd.Kfz.223 Army German Model 1/43 Panzerspahwagen Tanks & Military Vehicles

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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