42RH 40RH A500 42RE CHEROKEE GRAND JEEP 93-95 TRANSDUCER PRESSURE GOVERNOR 44RE Car & Truck Automatic Transmission Parts


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A500 40RH 42RH 42RE 44RE GOVERNOR PRESSURE TRANSDUCER 93-95 JEEP GRAND CHEROKEE
Condition: New Brand:

Rostra

Other Part Number: 50-1020 Manufacturer Part Number:

12415A

Warranty: Yes Interchange Part Number: 56027562
published on tue nov 09 2021

42RH 40RH A500 42RE CHEROKEE GRAND JEEP 93-95 TRANSDUCER PRESSURE GOVERNOR 44RE Car & Truck Automatic Transmission Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

42RH 40RH A500 42RE CHEROKEE GRAND JEEP 93-95 TRANSDUCER PRESSURE GOVERNOR 44RE Car & Truck Automatic Transmission Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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