GOLD NAPA 6600 AIR WIX) (46600 FILTER Car & Truck Air Filters


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6600 NAPA GOLD AIR FILTER (46600 WIX)
Condition: New Brand:

Wix

Country/Region of Manufacture: United States Manufacturer Part Number:

46600

Interchange Part Number: 46600 MPN:

46600

Other Part Number: A1538C PA3629 R800103 AF4567 CA8891 LAF1804

published on tue nov 09 2021

GOLD NAPA 6600 AIR WIX) (46600 FILTER Car & Truck Air Filters

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

GOLD NAPA 6600 AIR WIX) (46600 FILTER Car & Truck Air Filters

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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