Chevrolet 1988-1992  For about Details C1500 1990 1991 1989 38913TC Delco AC Compressor A/C Car & Truck A/C Compressors & Clutches


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Details about   For 1988-1992 Chevrolet C1500 A/C Compressor AC Delco 38913TC 1989 1991 1990
Condition: New Brand: AC Delco
Years: 1989 1988 1991 1990 1992 Part Number: 38913TC
Application: Chevrolet C1500 A/C Compressor Warranty: 12 Month Warranty
Product Name: A/C Compressor Notes: GM Original Equipment
CS-SKU: 400:38913TC


published on tue nov 09 2021

Chevrolet 1988-1992  For about Details C1500 1990 1991 1989 38913TC Delco AC Compressor A/C Car & Truck A/C Compressors & Clutches

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Chevrolet 1988-1992  For about Details C1500 1990 1991 1989 38913TC Delco AC Compressor A/C Car & Truck A/C Compressors & Clutches

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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