Crown Princess Personalized Night Colors LED 16 - Lamp Night Room Kids - Light Night Lights


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Personalized Princess Crown Night Light - Kids Room Night Lamp - 16 LED Colors
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Light Source: LED
Features: Personalized, Customized, 16 Colors, Name Engraved, Color Changing, USB Powered, With Remote Control Model:

Customized Night Light

Color:

16 Multi-Color

Country/Region of Manufacture: United States
MPN:

n/a

Sensor Type: Light
Room: Any Room Theme: Princess Crown
Age Group: Baby, Kid Power Source: Battery, Electric/Corded
Brand:

Handmade by Mirror Magic

Type: Night Light
UPC:

n/a








published on tue nov 09 2021

Crown Princess Personalized Night Colors LED 16 - Lamp Night Room Kids - Light Night Lights

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Crown Princess Personalized Night Colors LED 16 - Lamp Night Room Kids - Light Night Lights

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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