Blowoff 71002-AF002 HKS Valve Kit Recirculation SSQV Components Car & Truck Turbo Chargers & Parts


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HKS 71002-AF002 Blowoff Valve Components SSQV Recirculation Kit
Condition: New Working Hours: M-TH 8am - 8pm EST FRI 8am - 5pm
Manufacturer Part Number:

71002-AF002

Interchange Part Number: HKS_71002-AF002
UPC:

4957266262252

wUnderCarParts Call Center: Toll Free Number 888-986-3373
Country/Region of Manufacture: United States Brand:

HKS

Warranty: Yes
published on tue nov 09 2021

Blowoff 71002-AF002 HKS Valve Kit Recirculation SSQV Components Car & Truck Turbo Chargers & Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Blowoff 71002-AF002 HKS Valve Kit Recirculation SSQV Components Car & Truck Turbo Chargers & Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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