cm- 50x50x8 recycling-measures Iron in  "hashtags" about Details show title original Other Home Décor


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Details about   "hashtags" in Iron recycling-measures 50x50x8 cm- 							 							show original title
Condition: Seller refurbished: The item has been restored to working order by the eBay seller or a third party. This means the item Marca: - Fatto a mano -
Larghezza: 8 cm Colore: Rame
MPN: Non applicabile Lunghezza: 50 cm
Altezza: 50 cm Tipo: Figure
Materiale: Ferro











published on tue nov 09 2021

cm- 50x50x8 recycling-measures Iron in  "hashtags" about Details show title original Other Home Décor

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

cm- 50x50x8 recycling-measures Iron in  "hashtags" about Details show title original Other Home Décor

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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