ECC83 12AT7 12AU7 12AX7 Silicone Dampers Tube Vacuum 18mm 6Pcs EL84 USA 6922 Other Vintage Electronics Parts & Accessories


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6Pcs 18mm Vacuum Tube Dampers Silicone 12AX7 12AU7 12AT7 ECC83 EL84 6922 USA

published on tue nov 09 2021

ECC83 12AT7 12AU7 12AX7 Silicone Dampers Tube Vacuum 18mm 6Pcs EL84 USA 6922 Other Vintage Electronics Parts & Accessories

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

ECC83 12AT7 12AU7 12AX7 Silicone Dampers Tube Vacuum 18mm 6Pcs EL84 USA 6922 Other Vintage Electronics Parts & Accessories

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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