Zaun Profi WPC Sichtschutzzaun 180x183 anthrazit Gartenzaun Steckzaun Systemzaun Privacy Screens, Windscreens


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WPC Profi Zaun Sichtschutzzaun Systemzaun Steckzaun Gartenzaun anthrazit 180x183











published on tue nov 09 2021

Zaun Profi WPC Sichtschutzzaun 180x183 anthrazit Gartenzaun Steckzaun Systemzaun Privacy Screens, Windscreens

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Zaun Profi WPC Sichtschutzzaun 180x183 anthrazit Gartenzaun Steckzaun Systemzaun Privacy Screens, Windscreens

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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