CF50 ST70 Z50A Z50 C70 C65 C50 HONDA CF70 PCS. 2 ROCKER VALVE ARM CT70 CL70 S65 Other Motorcycle Parts


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HONDA C50 C65 C70 Z50 Z50A ST70 CF50 CF70 S65 CL70 CT70 ARM VALVE ROCKER 2 PCS.
Condition: New Manufacturer Part Number:

AM/1121

Brand:

AM SUPERCUB

published on tue nov 09 2021

CF50 ST70 Z50A Z50 C70 C65 C50 HONDA CF70 PCS. 2 ROCKER VALVE ARM CT70 CL70 S65 Other Motorcycle Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

CF50 ST70 Z50A Z50 C70 C65 C50 HONDA CF70 PCS. 2 ROCKER VALVE ARM CT70 CL70 S65 Other Motorcycle Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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