Large cm 38 Wooden Print MDF Antique Retro Decor Silent Home Room Clocks Wall Wall Clocks


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38 cm Large Wooden Wall Clocks Room Home Silent Decor Retro Antique MDF Print
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Features: 12 Hour Display, Battery Backup, Non-Ticking/Silent Sweep
Display Type: Digital MPN:

Does Not Apply

Item Weight: 0.6kg Department: Adults/Teens/Kids
Number Type: Roman Numerals Item Width: 38 cm
Engraved: No Frame Material: Wood Printed
Finish: Wooden Item Length: 38 cm
Brand:

UERMERSTAR

Item Height: 0.5cm
Style: European Era: 21st Century (2000-now)
Color:

Multicolor

Power Source: Battery Powered
Room: Bathroom, Bedroom, Dining Room, Garage, Home Office/Study, Kitchen, Laundry/Utility Room, Living Room, Playroom Material: MDF, Wooden Wall Clock
Theme: Retro & Lounge Year Manufactured: 2000
Character Family: Retro Model:

Round Wooden

Movement: Quartz (Battery Powered) Shape: Round
Type: Large Wall Clock Character: Retro
Original/Reproduction: Original UPC:

Does not apply






published on tue nov 09 2021

Large cm 38 Wooden Print MDF Antique Retro Decor Silent Home Room Clocks Wall Wall Clocks

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Large cm 38 Wooden Print MDF Antique Retro Decor Silent Home Room Clocks Wall Wall Clocks

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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