Plant Tall Plastic Pots Cactus Orchid for Drainage with Planters Pots Flower Baskets, Pots & Window Boxes


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Plastic Tall Plant Pots Flower Pots Planters with Drainage for Orchid Cactus
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Brand:

Unbranded

Material: Plastic Country/Region of Manufacture: China
Quantity: One Design: Round
Room: Garden Designer/Brand: Unbranded
Shape: Round Features: Flower Pots
Style: Round MPN:

Does Not Apply

Type: Round Main Colour: Black
UPC:

Does not apply

ISBN:

Does not apply

EAN:

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published on tue nov 09 2021

Plant Tall Plastic Pots Cactus Orchid for Drainage with Planters Pots Flower Baskets, Pots & Window Boxes

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Plant Tall Plastic Pots Cactus Orchid for Drainage with Planters Pots Flower Baskets, Pots & Window Boxes

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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