2.5" Part Chandelier Prism Crystal Glass Cut Hole One 10Pcs Colonial Repair Lamp Prisms


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10Pcs One Hole Cut Glass Crystal Prism Chandelier Part 2.5" Colonial Lamp Repair
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Country/Region of Manufacture: China
Color:

Clear

Material: Glass, Crystal
Weight: 150G Type: Prisms
MPN:

Does not apply

Prism Size: 63mm
Model:

16033105

Hole Size: 3MM
upc: Does Not Apply Qty: 10PCS
GTIN: Does Not Apply




published on tue nov 09 2021

2.5" Part Chandelier Prism Crystal Glass Cut Hole One 10Pcs Colonial Repair Lamp Prisms

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

2.5" Part Chandelier Prism Crystal Glass Cut Hole One 10Pcs Colonial Repair Lamp Prisms

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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