Black COUGAR CUSTOM 16/42 Editions First #28 Wheels Hot 2002 w/Purple Spokes Pr5 Contemporary Manufacture


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2002 Hot Wheels #28 First Editions 16/42 CUSTOM COUGAR Black w/Purple Pr5 Spokes
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Gender: Boys & Girls
Features: Purple Pr5 Spoke Wheels, Unopened Box Vehicle Make: Mercury
Year of Manufacture: 2002 Model:

Custom Cougar

Color:

Black

Modified Item: No
MPN:

52927-E910

Country/Region of Manufacture: Malaysia
Vehicle Type: Car Custom Bundle: No
Vehicle Year: 2001 Material: Die-Cast Metal / Plastic
Character Family: Die Cast Cars Theme: First Editions
Age Level: 3-4 Years, 4-7, 8-11 Years, 12-16 Years, 17 Years & Up Scale: 1:64
Brand:

Hot Wheels

Series: Hot Wheels 2002 First Editions
Recommended Age Range: 3+ UPC:

074299098901













published on tue nov 09 2021

Black COUGAR CUSTOM 16/42 Editions First #28 Wheels Hot 2002 w/Purple Spokes Pr5 Contemporary Manufacture

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Black COUGAR CUSTOM 16/42 Editions First #28 Wheels Hot 2002 w/Purple Spokes Pr5 Contemporary Manufacture

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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