83420-20020 Coolant Lexus Dodge MITSUBISHI TOYOTA For Fit Sensor Temperature Other Car & Truck Cooling Systems


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83420-20020 Coolant Temperature Sensor Fit For TOYOTA MITSUBISHI Dodge Lexus
Condition: New Superseded Part Number: 83420-20020
Manufacturer Part Number:

83420-20020 ,83420-20010, 83420-16010 ,8342016010

Modified Item: No
Other Part Number: 8342020020 ,83420 20020 Custom Bundle: No
Brand:

Unbranded

Interchange Part Number: 8342020020, 83420 20020
Fitment Type: Direct Replacement Surface Finish: BRAND NEW
Warranty: 2 Year UPC:

Does not apply








published on tue nov 09 2021

83420-20020 Coolant Lexus Dodge MITSUBISHI TOYOTA For Fit Sensor Temperature Other Car & Truck Cooling Systems

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

83420-20020 Coolant Lexus Dodge MITSUBISHI TOYOTA For Fit Sensor Temperature Other Car & Truck Cooling Systems

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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