Vegetable Holder Bowl Basket Fruit Wire Metal Art Iron Kitchen Storage Uk Decor Racks & Holders


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Kitchen Iron Art Metal Wire Fruit Basket Bowl Holder Vegetable Storage Decor Uk
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Bundle Description: No
Item Length: 13cm/5.11in Brand:

Unbranded

Item Width: 25cm /9.84in MPN:

Does Not Apply

Item Height: 10cm/3.93in Type: Fruit Basket
Personalised: No Custom Bundle: No
Style: Nordic Material: Iron
Mounting: Free Standing Item Weight: 350g
Shape: Simple








published on tue nov 09 2021

Vegetable Holder Bowl Basket Fruit Wire Metal Art Iron Kitchen Storage Uk Decor Racks & Holders

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Vegetable Holder Bowl Basket Fruit Wire Metal Art Iron Kitchen Storage Uk Decor Racks & Holders

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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