+ 4" Pieces Chess Rosewood Ringy Knight) (Biggie Staunton Rio 2 Queens Extra Contemporary Chess


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Rio Staunton (Biggie Knight) Ringy Rosewood Chess Pieces 4" + 2 Extra Queens
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Gender: All
MPN:

NA

Country/Region of Manufacture: India
Brand:

House of Chess

Material: Wood
Recommended Age Range: 5+ Color:

Natural Color of Wood

UPC:

Does not apply







published on tue nov 09 2021

+ 4" Pieces Chess Rosewood Ringy Knight) (Biggie Staunton Rio 2 Queens Extra Contemporary Chess

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

+ 4" Pieces Chess Rosewood Ringy Knight) (Biggie Staunton Rio 2 Queens Extra Contemporary Chess

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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