Male BLUE 300 Vinyl 2-250 MDD AWG 16-14 Terminal Connector Wire Spade Insulated Car Audio & Video Connectors & Terminals


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300 BLUE Male Vinyl  Insulated Spade Wire Connector Terminal 16-14 AWG MDD 2-250
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is MPN:

Does Not Apply

Quantity: 300 Gauge: 16-14
Color:

blue

Brand:

PAKA TOOLS

UPC:

Does not apply

published on tue nov 09 2021

Male BLUE 300 Vinyl 2-250 MDD AWG 16-14 Terminal Connector Wire Spade Insulated Car Audio & Video Connectors & Terminals

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Male BLUE 300 Vinyl 2-250 MDD AWG 16-14 Terminal Connector Wire Spade Insulated Car Audio & Video Connectors & Terminals

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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