64 FAN 16" & SHROUD RADIATOR ALUMINUM KKS 65 Core W 24" Camino El 60 59 Chevelle Car & Truck Radiators & Parts


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KKS ALUMINUM RADIATOR SHROUD & 16" FAN 64 65 Chevelle 59 60 El Camino 24" W Core
Condition: New Modified Item: No
Manufacturer Part Number:

KKS281FS

Custom Bundle: No
Brand:

KKS

Interchange Part Number: KKS281
Fitment Type: Direct Replacement Material: Aluminum
Non-Domestic Product: No Type: Fan Shroud
Warranty: Lifetime Color:

Silver

Mounting Hardware Included: No UPC:

Does not apply






published on tue nov 09 2021

64 FAN 16" & SHROUD RADIATOR ALUMINUM KKS 65 Core W 24" Camino El 60 59 Chevelle Car & Truck Radiators & Parts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

64 FAN 16" & SHROUD RADIATOR ALUMINUM KKS 65 Core W 24" Camino El 60 59 Chevelle Car & Truck Radiators & Parts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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