T-Strap Blue Royal Sandal Clothes Doll Girl American 18" for made Shoes Modern Doll Clothes & Fashion Accs


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Royal Blue T-Strap Sandal Shoes made for 18" American Girl Doll Clothes
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's For Doll Size: 18in.
Environment: Smoke Free Store: Dori's Doll Boutique
Type: Shoes Product Type: Doll Shoes
Shipping Promo: USA orders over $35 ship for free Shoe Type: Royal Blue T-Strap Sandals
MPN:

050b

Size: 2 3/4 inches long
Clothing Type: Shoes Color:

Royal Blue

Character Family: American Girl Also fits: Bitty Baby & Bitty Twin Dolls
Brand:

Dori's Doll Boutique

Era: Modern
Recommended Age Range: 5+ Safety Tested: Yes
UPC:

Does Not Apply






published on tue nov 09 2021

T-Strap Blue Royal Sandal Clothes Doll Girl American 18" for made Shoes Modern Doll Clothes & Fashion Accs

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

T-Strap Blue Royal Sandal Clothes Doll Girl American 18" for made Shoes Modern Doll Clothes & Fashion Accs

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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