Craig Frames Frame Picture Wood Gold Antique Distressed 2.2" Contemporary, Frames


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Craig Frames Contemporary, 2.2" Distressed Antique Gold Wood Picture Frame
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Shape: Rectangle
Suitable for Photo Size: Various Sizes Color:

Bronze

Brand:

Craig Frames

Model:

9671

Theme: Family & Friends Country/Region of Manufacture: United States
Photo Size: Various Sizes MPN:

9671

Material: Wood Style: Contemporary
Dominant Color: Bronze Frame Width: Various Sizes
Type: Single Hanging Frame Frame Material: Wood
Modified Item: No Frame Height: Various Sizes
Non-Domestic Product: No









published on tue nov 09 2021

Craig Frames Frame Picture Wood Gold Antique Distressed 2.2" Contemporary, Frames

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Craig Frames Frame Picture Wood Gold Antique Distressed 2.2" Contemporary, Frames

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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