Handmade ILIV Metallic Geometric Cover Cushion Fabric Graphite in JAZZ Nautical Home Décor Pillows


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Handmade ILIV JAZZ in Graphite Fabric Cushion Cover Geometric Metallic
Condition: Open box: An item in excellent, new condition with no wear. The item may be missing the original packaging or Modified Item: No
Brand:

Handmade By Perfectcushionsuk

Custom Bundle: No
Non-Domestic Product: No Theme: Art
Material: 100% Polyester Type: Cushion Cover
Pattern: Geometric Main Colour: Graphite, Silver Grey
Style: Art Deco Style






published on tue nov 09 2021

Handmade ILIV Metallic Geometric Cover Cushion Fabric Graphite in JAZZ Nautical Home Décor Pillows

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Handmade ILIV Metallic Geometric Cover Cushion Fabric Graphite in JAZZ Nautical Home Décor Pillows

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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