MENS BAHAMA TOMMY HAWAIIAN $125 NWT 3XL 2XL XL SHIRT CAMP BOTANICAL ROYAL SILK Casual Button-Down Shirts


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TOMMY BAHAMA MENS HAWAIIAN SILK ROYAL BOTANICAL CAMP SHIRT XL 2XL 3XL NWT $125
Condition: New with tags: A brand-new, unused, and unworn item (including handmade items) in the original packaging (such as Modified Item: No
Type: Shirts Country/Region of Manufacture: China
Gender: Men Style: Hawaiian
Color:

CASTAWAY GREEN

Material: 100% Silk
Sleeve Length: Short Sleeve Pattern: Floral
Brand:

Tommy Bahama

Fit: Original fit
Size Type: Regular



published on tue nov 09 2021

MENS BAHAMA TOMMY HAWAIIAN $125 NWT 3XL 2XL XL SHIRT CAMP BOTANICAL ROYAL SILK Casual Button-Down Shirts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

MENS BAHAMA TOMMY HAWAIIAN $125 NWT 3XL 2XL XL SHIRT CAMP BOTANICAL ROYAL SILK Casual Button-Down Shirts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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