500 300 CMX REBEL HONDA FIT 17-19 BLACK GLOSS RACK BAR SUPPORT BAG SADDLE STEEL Motorcycle Saddlebags & Accessories


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FIT HONDA REBEL CMX 300 500 17-19 STEEL SADDLE BAG SUPPORT BAR RACK GLOSS BLACK
Condition: New Colour: Black
Features: Extended Saddlebags Modified Item: No
Color:

Black

Country/Region of Manufacture: Thailand
Manufacturer Part Number:

SADDLE BAG BARS HONDA REBEL

Custom Bundle: No
Brand:

Honda

Material: Steel
Non-Domestic Product: No Type: Saddlebag
Warranty: 60 Day UPC:

N/A











published on tue nov 09 2021

500 300 CMX REBEL HONDA FIT 17-19 BLACK GLOSS RACK BAR SUPPORT BAG SADDLE STEEL Motorcycle Saddlebags & Accessories

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

500 300 CMX REBEL HONDA FIT 17-19 BLACK GLOSS RACK BAR SUPPORT BAG SADDLE STEEL Motorcycle Saddlebags & Accessories

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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