keychain Mini 1Pc key 1m_GG ruler pull measure tape retractable easy ring Home Measuring Tapes & Rulers


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1Pc Mini keychain key ring easy retractable tape measure pull ruler 1m_GG
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Country/Region of Manufacture: China
Brand:

Unbranded

System of Measurement: Metric
Type: Ruler Length: 1M
GTIN: Unbranded MPN:

Does Not Apply

Manufacturer Part Number:

Does not apply













published on tue nov 09 2021

keychain Mini 1Pc key 1m_GG ruler pull measure tape retractable easy ring Home Measuring Tapes & Rulers

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

keychain Mini 1Pc key 1m_GG ruler pull measure tape retractable easy ring Home Measuring Tapes & Rulers

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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