CI 325I CI Fits:323I Sensor Flow Air Mass 325XI Z3 528I 525I 328IS 328CI 328I Car & Truck Air Intake & Fuel Delivery Sensors


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Mass Air Flow Sensor Fits:323I CI 325I CI 325XI 328I 328CI 328IS  525I 528I  Z3
Condition: New Interchange Part Number: 13 62 1 432 356
Brand:

Aftermarket

Manufacturer Part Number:

13621432356

UPC:

641517847834



published on tue nov 09 2021

CI 325I CI Fits:323I Sensor Flow Air Mass 325XI Z3 528I 525I 328IS 328CI 328I Car & Truck Air Intake & Fuel Delivery Sensors

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

CI 325I CI Fits:323I Sensor Flow Air Mass 325XI Z3 528I 525I 328IS 328CI 328I Car & Truck Air Intake & Fuel Delivery Sensors

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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