about Details  Soft Shoes Home Comfortable Winter Warm Furry Slip Non Slippers Indoor Men Plush Slippers


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Details about   Soft Plush Men Indoor Slippers Non Slip Furry Warm Winter Comfortable Home Shoes
Condition: New with box: A brand-new, unused, and unworn item (including handmade items) in the original packaging (such as Size: See variations
Heel Height: Flat (≤1cm) Model: 0259781140
Type: Slipper Country/Region of Manufacture: China
Features: Non-Slip Department: Women
Upper Material: Flock Department Name: Adult
MPN: 0259781162 Style: Flat
Insole Material: Short Plush Applicable Place: Indoor
Character Family: Home Shoes Type: Basic
Brand: Unbranded Item Type: Slippers
Lining Material: Short Plush Fit: Normal size
Pattern Type: Solid Season: Winter
Fashion Element: Sewing Outsole Material: PVC















published on tue nov 09 2021

about Details  Soft Shoes Home Comfortable Winter Warm Furry Slip Non Slippers Indoor Men Plush Slippers

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

about Details  Soft Shoes Home Comfortable Winter Warm Furry Slip Non Slippers Indoor Men Plush Slippers

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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