Photo Sheets 1000 Paper Printer Laser a4 x Gloss Glossy gr 250 Other Printing & Graphic Arts


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1000 Sheets Photo Paper 250 gr Glossy Gloss x a4 Laser Printer
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Nuovo/Usato: Nuovo
MPN:

0251x1000

Peso: 250 gsm
Marca: New Paper Tipo: Patinata
Articoli nella confezione: 1000 fogli Formato carta: A4 (210 mm x 297 mm)
Finitura carta: Lucida EAN:

0701197327115

published on tue nov 09 2021

Photo Sheets 1000 Paper Printer Laser a4 x Gloss Glossy gr 250 Other Printing & Graphic Arts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Photo Sheets 1000 Paper Printer Laser a4 x Gloss Glossy gr 250 Other Printing & Graphic Arts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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