Athearn HO #9275 LS&I Load with Car Ore Ribbed 24' Freight Cars


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Athearn HO 24' Ribbed Ore Car with Load LS&I #9275
Condition: New: A brand-new, unused, unopened, undamaged item (including handmade items). See the seller's Brand:

Athearn

MPN:

RND87147

UPC:

797534871472

published on tue nov 09 2021

Athearn HO #9275 LS&I Load with Car Ore Ribbed 24' Freight Cars

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Athearn HO #9275 LS&I Load with Car Ore Ribbed 24' Freight Cars

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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