17x7.5 Enkei PDC 4x100 +42 Gloss Black Wheel (1 Rim only) Enkei Car and Truck Wheels


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17x7.5 Enkei PDC 4x100 +42 Gloss Black Wheel (1 Rim only)
Condition: New Size: 17x7.5
Warranty: 1 Year Finish: Gloss Black
Rim Diameter: 17 Product Model: PDC
Rim Width: 7.5 Rim Material: Alloy
Fitment Note: Please Contact Us to Confirm Fitment Rim Structure: One Piece
Quantity: 1 Bolt Pattern: 4x100
Lugs: NOT Included Offset: 42
Manufacturer Part Number:

502-775-4942BK

Hub Bore: 72.6
Brand:

Enkei

Weight: 22.5
UPC:

NA



published on tue nov 09 2021

17x7.5 Enkei PDC 4x100 +42 Gloss Black Wheel (1 Rim only) Enkei Car and Truck Wheels

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

17x7.5 Enkei PDC 4x100 +42 Gloss Black Wheel (1 Rim only) Enkei Car and Truck Wheels

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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