For Art Wall Poster Horse Animal Canvas on Print Painting Home Modern Decor Vintage Sea Life Home Décor Posters & Prints


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Painting Print on Canvas Animal Horse Poster Wall Art For Home Decor Modern
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Style: Art Deco
Type: Material: Canvas
Color:

Multicolor

Original/Reproduction: Original Print
Subject: Animal horse Date of Creation: 2000-Now
Signed: Unsigned Print Type: Giclee & Iris Print
Brand:

homeart

Frame: unframes
Size: 30*40cm UPC:

Does not apply

published on tue nov 09 2021

For Art Wall Poster Horse Animal Canvas on Print Painting Home Modern Decor Vintage Sea Life Home Décor Posters & Prints

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

For Art Wall Poster Horse Animal Canvas on Print Painting Home Modern Decor Vintage Sea Life Home Décor Posters & Prints

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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