Flat Phillips (250) Head Point Tek #3 Screws Wing Reamer Self-Drilling 2 x 12-24 Industrial Screws & Bolts


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(250) Phillips Flat Head 12-24 x 2 Self-Drilling Reamer Wing Screws #3 Tek Point
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Fastener Type: Screws
Quantity: 250 Drive Type: Phillips
Screw Type: Self-Drilling Screws Head Style: Flat
Thread Length: 2 Coating: Zinc
Unit of Measurement: Inch Material: Steel
Thread Design: Reamer Wing Brand:

Lexar Industrial

Length: 2 MPN:

201459816825

Thread Diameter: #12-24
published on tue nov 09 2021

Flat Phillips (250) Head Point Tek #3 Screws Wing Reamer Self-Drilling 2 x 12-24 Industrial Screws & Bolts

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Flat Phillips (250) Head Point Tek #3 Screws Wing Reamer Self-Drilling 2 x 12-24 Industrial Screws & Bolts

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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