Angle Right Double 3.5mm 1m DFDE Male Bla Wire Lead Cord Cable Audio Stereo Plug Audio Cables & Adapters


  1. Home
  2. Angle Right Double 3.5mm 1m DFDE Male Bla Wire Lead Cord Cable Audio Stereo Plug
  1. facebook
  2. twitter
  3. linkedin
  4. pinterest
DFDE 1m 3.5mm Double Right Angle Male Plug Stereo Audio Cable Cord Lead Wire Bla
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Brand:

Unbranded

EAN:

Does not apply

MPN:

Does not apply

Manufacturer Part number: Does not apply UPC:

692555788290









published on tue nov 09 2021

Angle Right Double 3.5mm 1m DFDE Male Bla Wire Lead Cord Cable Audio Stereo Plug Audio Cables & Adapters

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Angle Right Double 3.5mm 1m DFDE Male Bla Wire Lead Cord Cable Audio Stereo Plug Audio Cables & Adapters

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

509
1.2k
EVGENIA.RU RSS