98-05 for Black Textured Handle Door Outside 4 of Set Explorer Mountaineer & Car & Truck Exterior Door Handles


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Set of 4 Outside Door Handle Textured Black for 98-05 Explorer & Mountaineer
Condition: New Interchange Part Number: EXPLORER/ MOUNTAINEER 98-01
Placement on Vehicle: Front, Left Side, Front, Right Side, Rear, Left Side, Rear, Right Side Type: SPORT TRAC 01-05
Other Part Number: SPORT 01-03 Surface Finish: TEXTURED BLACK
Brand:

OUTER EXTERIOR OUTSIDE DOOR HANDLE HANDEL

Manufacturer Part Number:

3L2Z-7822404-BA, 3L2Z7822404BA

published on tue nov 09 2021

98-05 for Black Textured Handle Door Outside 4 of Set Explorer Mountaineer & Car & Truck Exterior Door Handles

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

98-05 for Black Textured Handle Door Outside 4 of Set Explorer Mountaineer & Car & Truck Exterior Door Handles

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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