Aluminium MTB 11T Jockey Bear Guide Pulley Derailleur Rear Bike Bicycle Wheel Derailleurs (Rear)


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11T MTB Aluminium Jockey Wheel Bicycle Bike Rear Derailleur Pulley Guide Bear
Condition: New: A brand-new, unused, unopened, undamaged item in its original packaging (where packaging is Teeth:: 11T
Size:: 5mm (D) Model:

11T

Net Weight:: 9.8g Modified Item: No
Inner diameter:: about 5.2mm Country/Region of Manufacture: China
Non-Domestic Product: No Custom Bundle: No
Type: 11 Gear Guide Pulley Bearings:: Upgraded RS bearing.
MPN:

FXH1647746491978XC

Material:: Aluminium
Brand:

Unbranded




















published on tue nov 09 2021

Aluminium MTB 11T Jockey Bear Guide Pulley Derailleur Rear Bike Bicycle Wheel Derailleurs (Rear)

gandhi, s., klein, j., robertson, a., pena-hernandez, m. a.,

Aluminium MTB 11T Jockey Bear Guide Pulley Derailleur Rear Bike Bicycle Wheel Derailleurs (Rear)

lin, m. j., roychoudhury, p., lu, p., fournier, j., ferguson, d., mohamed bakhash, s. a., muenker, m. c., srivathsan, a., wunder, e. a., kerantzas, n., wang, w., pyle, a., wilen, c. b., ogbuagu, o., greninger ,, a. l., iwasaki, a., schulz, w. l., ko, a. i.

sars-cov-2 remdesivir resistance mutations have been generated in vitro but have not been reported in patients receiving treatment with the antiviral agent. we present a case of an immunocompromised patient with acquired b-cell deficiency who developed an indolent, protracted course of sars-cov-2 infection. remdesivir therapy alleviated symptoms and produced a transient virologic response, but her course was complicated by recrudescence of high-grade viral shedding. whole genome sequencing identified a mutation, e802d, in the nsp12 rna-dependent rna polymerase which was not present in pre-treatment specimens. in vitro experiments demonstrated that the mutation conferred a ~6-fold increase in remdesivir ic50 but resulted in a fitness cost in the absence of remdesivir. sustained clinical and virologic response was achieved after treatment with casirivimab-imdevimab. although the fitness cost observed in vitro may limit the risk posed by e802d,

, this case illustrates the importance of monitoring for remdesivir resistance and the potential benefit of combinatorial therapies in immunocompromised patients with sars-cov-2 infection.

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